small fiberglass tanks. They can be customized to meet specific requirements, whether it's in terms of shape, size, or additional features like insulation or secondary containment. This customization capability makes them suitable for diverse applications, from rainwater harvesting systems to industrial chemical storage.Our most popular FRP product, molded square mesh grating is available in 1”, 1-1/2”, and 2” depths. The 1” and 1-1/2” deep products are produced with a 1-1/2” square mesh while the 2” deep products are produced with a 2” square mesh. The square pattern of the panels provides bi-directional strength and facilitates easy layout and fabrication.
Data on chronic toxicity and carcinogenicity are available for microcrystalline cellulose (E 460), methyl cellulose (E 461) hydroxypropyl cellulose (E 463), HPMC (E 464) and sodium carboxymethyl cellulose (E 466). Some studies were unfit for evaluation due to methodological shortcomings. In the only relevant study, the dietary administration of even high doses of microcrystalline cellulose (E 460) (30%, 15,000 mg/kg bw) to rats for 72 weeks did not affect survival, feed efficiency or haematology. Apart from some dystrophic calcification in renal tubules, no other relevant lesions were noted and tumour incidence did not differ with that of controls. Several studies were conducted in rats with methyl cellulose (E 461) via feed or drinking water or by gavage at concentrations up to 5% (2,500 mg methyl cellulose/kg bw per day) and for up to 2 years. For all examined parameters, no adverse effects were reported and also the observed tumours did not differ in type and number in treated and control groups. In the only identified study, the daily dosing of male and female rats (0, 1,500, 3,000 or 6,000 mg hydroxypropyl cellulose/kg bw) via gavage for 6 months did not cause adverse effects (including carcinogenicity) apart from a decrease in body weight in high-dosed rats (statistically significant in females only). Apart from a decrease in body weights of high-dosed males, no other significant adverse findings were reported and there was no indication of a carcinogenic effect in rats of either sex dietary exposed to HPMC (E 464) up to 20% (10,000 mg/kg bw per day) for 1 year. Carboxy methylcellulose (E 466) was tested in mice and rats at dosages of 0, 10,000 or 100,000 mg/kg diet (equivalent to 0, 1,500 or 15,000 mg/kg bw per day for mice and to 0, 500 or 5,000 mg/kg bw per day for rats) for up to 104 weeks. Despite the increase in feed intake, a treatment related decrease in body weight was noted at the end of the treatment. Histological examination revealed no intestinal abnormality or evidence of the passage of the additive across the intestinal wall in either species and the tumour incidences were comparable among groups.
The applicant did not provide new studies on the safety of HPMC, but made reference to previous assessment of celluloses (as a group) performed by other scientific bodies. Cellulose and cellulose derivatives were evaluated for their safety by JECFA (1990), which allocated a group ADI of ‘not specified’. The last comprehensive evaluation of cellulose and cellulose derivatives, including HPMC, for their use as food additives was done in 2017 by the ANS Panel (EFSA ANS Panel, 2018), which concluded that there was no need to set a numerical ADI. Although the data set available for the different celluloses is not complete and most of the studies were old and do not meet the current requirements of toxicological testing, the ANS Panel considered that the physico-chemical, structural, biological and kinetic similarities between the modified celluloses make it possible to apply a read-across approach among the different celluloses.
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Many manufacturers have also prioritized research and development efforts to improve the quality and performance of their HPMC products, ensuring they meet the stringent requirements of various industries Many manufacturers have also prioritized research and development efforts to improve the quality and performance of their HPMC products, ensuring they meet the stringent requirements of various industrieshpmc manufacturers in china.Hydroxypropyl methyl cellulose (E 464) is currently authorised as a feed additive for all animal species, without a minimum and a maximum content. It is also authorised, quantum satis, for use as a food additive.
The growing demand for processed and convenience foods, along with the rising awareness about clean-label ingredients, is fostering the growth of HPMC in this sector The growing demand for processed and convenience foods, along with the rising awareness about clean-label ingredients, is fostering the growth of HPMC in this sectorhpmc market.In ophthalmology it is used due to its good wetting properties, excellent tissue and endothelium protection, efficient volume replacement and quick removal. Specifically, it can be used to wet the cornea during cataract, corneal or retinal procedures.
